|
Publications |
|
We have developed a highly efficient and simple method for making a wide variety of chiral diamines from a single ‘mother’ diamine and recently reported some of our preliminary theoretical[1] and practical[2,3] studies. Density functional theory computation shows that resonance assisted H-bonds direct the diaza-Cope rearrangement reaction to completion in the synthesis of our diamines (demo). Some of our chiral diamines have been used as organocatalysts for stereoselective synthesis of the blood thinning agent warfarin.[4] More recently we have used the meso ‘mother’ diamine in the development of a metal complex with imprintable chiral memory[5] for stereoselective recognition of amino acids and catalysis.[6,7] |
|
Publications |
|
DiaminoPharm Inc |
|
Chiral catalysts and therapeutics |
|
[1] J. Chin; F. Mancin; N. Thavarajah; D. Lee; D. S. Chung J. Am. Chem. Soc. (2003) p15276-15277. [2] H.-J. Kim; H. Kim; G. Alhakimi; E. J. Jeong; N. Thavarajah; L. Studnicki; A. Koprianiuk; A. J. Lough; J. Suh; J. Chin J. Am. Chem. Soc. (2005) p16370-16371. [3] H.-J. Kim; W. Kim; A. Lough; B. M. Kim; J. Chin J. Am. Chem. Soc. (2005) p16776-16777. [4] H. Kim; C. Yen; P. Preston; J. Chin Org. Lett. (2006) p5239-5242. [5] J. Chin; Y. S. Chong; R. Bobb; L. Studnicki; J.-I. Hong Chem. Comm. (2007) p120-122. [6] H. Park; K. M. Kim; A. Lee; S. Ham; W. Nam; J. Chin J. Am. Chem. Soc. (2007) p1518- 1519. Highlighted in Science. [7] J. Chin; S. S. Lee; K. J. Lee; S. Park; D. H. Kim Nature, (1999) 401, p254-257. |
|
706-880 Grandview Way Toronto, Ontario Canada M2N 7B2 |
|
Phone: 416-453-6778 Fax: 416-978-7113 E-mail: info@diaminopharm.com Webmaster: jchin@chem.utoronto.ca |
|
To contact us: |
|
Copyright © 2007 DiaminoPharm Inc. All right reserved |
