Generating functional libraries to accelerate the search for next-generation materials
Accelerating materials innovation and discovery through rapid generation of functional libraries
We use our proprietary platform for diamine synthesis to rapidly generate libraries of catalysts, artificial peptides, and organic materials.
Consider just about any major challenge we face today and materials are at the centre of it. To build a more sustainable and cleaner future, the world needs biodegradable plastics, more efficient batteries, enhanced coatings for precision drug delivery to just name a few. Traditionally, materials development has been a slow and painstaking process but with the advent of powerful simulation techniques aided by artificial intelligence and automation, vast libraries can be rapidly screened, vastly accelerating the development of new materials. The world is now on the cusp of another materials revolution and this new era of innovation will bring transformative new products integral to a cleaner and more sustainable future.
OUR X-PEPTIDES
X-Peptides are the only constitutional isomer of natural peptides - constructed from diamines and diacids instead of amino acids. In X-peptides, the position of carbon atoms along the peptide backbone has been "exchanged" relative to natural peptides. The stereogenic carbons are found adjacent in a vicinal relationship which reduces the flexibility of the backbone and acts as a control element for the secondary structure where chiral diamines exclusively form helices and meso diamines exclusively form sheets.
natural peptide
x-peptide
X-PEPTIDES - NOVEL PEPTIDOMIMETIC
Developed in the lab of Jik Chin at the University of Toronto
Helical X-Peptides -
chiral diamines
Sheet X-Peptides -
meso diamines
Libraries of x-peptides can be synthesized using automated solid-phase peptide synthesis (SPPS) from a diverse range of diamine monomers. Libraries of x-peptides can be screened for applications in a broad range of areas, such as medicinal chemistry, enantioselective catalysis, stereoselective molecular recognition, organic electronic materials, and bio-compatible and bio-degradable materials.
Modular amino acid monomers
Simple building blocks
No racemisation
X-Peptide Hybrids
X-peptides form hybrids with natural peptides
OUR DIAMINES
Chiral diamines are a really powerful class of compounds because the scope of the catalysts is not limited to one type of transformation. Since we can easily make an unlimited number of chiral diamines from our mother diamine, people can and have screened the diamines to optimize their catalytic transformations.
DIAZA-COPE REARRANGEMENT FOR MOTHER TO DAUGHTER CONVERSION
Broad substrate scope
100s of daughter
diamines available
Highly
stereospecific
Developed in the lab of Jik Chin at the University of Toronto
Highly
scalable
Both chiral and meso diamines are available
Our technology allows us to synthesize an unlimited number of chiral diamines, and in turn, these chiral diamines can be incorporated into a variety of diverse catalysts and ligands. These catalysts and ligands are used for wide assortment of chemical transformations. Diamines are also used in building blocks in a lot of pharmaceutical drugs or catalysts in the synthesis of drugs.
DIAMINES IN CATALYSIS
Transfer Hydrogenation
R. Noyori - JACS, 1995, 7562
Enantioconvergent alkyl boronate formation
G. Fu - Science, 2016, 1265
Lewis base for C-C
bond formation
S. Denmark - Acc. Chem. Res.
2000, 432
Asymmetric epoxidation
and hydrolysis
E. Jacobsen - JACS, 1991, 7063
DIAMINES IN PHARMA
Tamiflu
Hoffmann-La-Roche
Lorabid
King Pharmaceuticals
Catalyst in Synthesis
of Prevymis
Merck
Nutlin-3
HOffmann-La-Roche
OUR AMINO ACIDS
Amino acids are ubiquitously found in all biological systems and are one of the most important building blocks of life. Consequently, unnatural amino acids have served as important building blocks for the drug discovery process. Our process allows for the rapid synthesis of a wide variety of unnatural amino acids in an enantiopure fashion.
SOLUBILITY-INDUCED DIASTEREOMERIC TRANSFORMATION FOR L TO D CONVERSION
Developed in the lab of Jik Chin at the University of Toronto
Recyclable chiral auxiliary
Highly scalable
Diverse range of R groups available
Both enantiomers and deuterated variants are available
UNNATURAL AMINO ACIDS IN PHARMA
Keppra
UCB Pharmaceuticals
Plavix
Bristol-Myers Squibb, Sanofi
Quinapril
Pfizer
Enalapril
Merck
Saxagliptin
Bristol-Myers Squibb,
AstraZeneca
Tadalafil
Eli Lilly
DEUTERATED AMINO ACIDS IN PHARMA
d1-Avadomide
Salarius Pharmaceuticals
d1-Pomalidomide
Deuterx
d1-Lenalidomide
Bristol-Myers Squibb
